These articles were made available in honor of the 10th Autoimmunity Congress and are available for free until June 1, 2016.
About the Congress of Autoimmunity
The theme of both this and the previous nine Congresses of Autoimmunity have centered on presentation of cutting-edge scientific papers whose focus is to improve the care of our patients with autoimmunity. Each Congress has become more and more sophisticated with increasing use of technology and further involvement of scientists in many disciplines.
At the heart of the Congress, however, remains the patient. Autoimmunity has hit a wall. Although we have made enormous strides in dissecting the incredible promiscuous nature of the immune response, the reality is that we still lack precise understanding of etiology. The study of genetics, although yielding enormous amount of data and bioinformatics, has not led to any major breakthroughs. The introduction of biologics has certainly been a major stride for some autoimmune diseases such as rheumatoid arthritis, but has failed in many others, such as systemic lupus erythematosus.
On the other hand, the first textbook of autoimmunity was not published until 1963 by Ian Mackay and Sir Macfarland Burnet; that textbook recognized only a limited number of autoimmune diseases. We now know that there are more than 100 autoimmune diseases and all of them are distinctive and all may involve different etiologies and different effector pathways. In other words, at present there is no one size fits all.
Many immunologists have made the analogy of the immune response to Greek mythology and, in particular, to Achilles. Achilles became immortal because his mother scorched remnants of mortality with fire. However, this immortality did not include his heel and, as is well known, he eventually died of a poisoned arrow directed at this heel. It is an interesting analogy for immunologists between immunity and autoimmunity. All animals have an immune system and of course its sophistication increases with evolution. With such sophistication come increasing errors and these of course include immunodeficiency, but also autoimmunity.
About the Articles Selection
The following list of papers was extracted from approximately the last 18 months of the Journal of Autoimmunity and is intended to highlight the breadth of the immune response. It includes papers on Ebola, which may not directly impinge autoimmunity, but reflect the nature of the immune response. It also includes a scholarly paper on autism, which may well have some inflammatory components. And, of course, it includes cutting-edge papers in many fields that are being presented at this meeting. In the Journal of Autoimmunity, as in the Congress, the far-reaching goal is outstanding scholarship and ultimately translation of original investigation to improve patient care.
This is the 10th Congress. Will there be a 100th Congress and what will mankind, the immune response, and autoimmune diseases look like in 300 years? We wish we knew.
Yehuda Shoenfeld (Editor-in-Chief of Autoimmunity Reviews)
M. Eric Gershwin (Editor-in-Chief of Journal of Autoimmunity)
ARTICLE SELECTION JOURNAL OF AUTOIMMUNITY:
A T cell extrinsic mechanism by which IL-2 dampens Th17 differentiation
Ana C. Anderson, Jenna M. Sullivan, Dewar J. Tan, David H. Lee, Vijay K. Kuchroo
Journal of Autoimmunity, Volume 59, May 2015, Pages 38–42
Clinical features and pathobiology of Ebolavirus infection Review Article
Aftab A. Ansari
Journal of Autoimmunity, Volume 55, December 2014, Pages 1-9
Deleting the BAFF receptor TACI protects against systemic lupus erythematosus without extensive reduction of B cell numbers
William A. Figgett, Devy Deliyanti, Kirsten A. Fairfax, Pin Shie Quah, Jennifer L. Wilkinson-Berka, Fabienne Mackay
Journal of Autoimmunity, Volume 61, July 2015, Pages 9–16
Immunogenetics of systemic lupus erythematosus: A comprehensive review
Yogita Ghodke-Puranik, Timothy. B. Niewold
Journal of Autoimmunity, Volume 64, November 2015, Pages 125–136
ARTICLE SELECTION AUTOIMMUNITY REVIEWS:
Antonio Grecoa, Maria Ida Rizzob, Armando De Virgilioa, Andrea Galloc, Massimo Fusconia, Giovanni Ruoppoloa, Giancarlo Altissimid, Marco De Vincentiisa
Autoimmunity Reviews, Volume 14, Issue 4, April 2015, Pages 341–348
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Innate and adaptive immunity in inflammatory bowel disease
Alessandra Geremiaa, Paolo Biancheri, Philip Allana, Gino R. Corazza, Antonio Di Sabatino
Autoimmunity Reviews, Volume 13, Issue 1, January 2014, Pages 3–10
Zinc and its role in immunity and inflammation
Paola Bonaventura, Giulia Benedetti, Francis Albarède, Pierre Miossec
Autoimmunity Reviews, Volume 14, Issue 4, April 2015, Pages 277–285
T cell responses in psoriasis and psoriatic arthritis
Marco Diani, Gianfranco Altomare, Eva Reali
Autoimmunity Reviews, Volume 14, Issue 4, April 2015, Pages 286–292Access for Free